NFL Strong Safetys
| Name | Team | Tackle | Sack | Fumble | Int. |
| Michael M. Lewis | San Francisco 49ers | 104 | 1 | 1 | 2 |
| Chris Harris | Carolina Panthers | 96 | 0 | 8 | 1 |
| Sean Jones | Cleveland Browns | 96 | 0 | 1 | 5 |
| Bob Sanders | Indianapolis Colts | 96 | 3 | 0 | 2 |
| LaRon Landry | Washington Redskins | 95 | 1 | 0 | 0 |
| Roy Williams | Dallas Cowboys | 92 | 0 | 0 | 2 |
| Roman Harper | New Orleans Saints | 90 | 4 | 2 | 3 |
| Lawyer Milloy | Atlanta Falcons | 90 | 0 | 0 | 2 |
| Bernard Pollard | Kansas City Chiefs | 90 | 1 | 1 | 2 |
| Donte Whitner | Buffalo Bills | 89 | 0 | 1 | 1 |
| Kenoy Kennedy | Detroit Lions | 88 | 0 | 2 | 2 |
| Atari Bigby | Green Bay Packers | 86 | 0 | 3 | 5 |
| Clinton Hart | San Diego Chargers | 85 | 1 | 0 | 5 |
| Michael Huff | Oakland Raiders | 85 | 1 | 1 | 1 |
| C.C. Brown | Houston Texans | 84 | 0 | 2 | 1 |
| Jermaine Phillips | Tampa Bay Buccaneers | 83 | 1 | 3 | 4 |
| Dawan Landry | Baltimore Ravens | 82 | 1 | 0 | 0 |
| Deon Grant | Seattle Seahawks | 77 | 0 | 0 | 3 |
| Corey Chavous | St. Louis Rams | 75 | 3 | 1 | 0 |
| Quintin Mikell | Philadelphia Eagles | 74 | 1 | 1 | 1 |
| Dexter Jackson | Cincinnati Bengals | 72 | 0 | 1 | 2 |
| Rodney Harrison | New England Patriots | 68 | 2 | 1 | 1 |
| Brandon McGowan | Chicago Bears | 68 | 0 | 1 | 2 |
| Jordan Babineaux | Seattle Seahawks | 64 | 1 | 3 | 1 |
| Darren Sharper | Minnesota Vikings | 63 | 0 | 1 | 4 |
| Adam Archuleta | Chicago Bears | 61 | 2 | 0 | 1 |
| James Butler | New York Giants | 61 | 0 | 0 | 1 |
| Troy Polamalu | Pittsburgh Steelers | 58 | 0 | 3 | 0 |
| Tyrone Carter | Pittsburgh Steelers | 56 | 0 | 3 | 0 |
| Cameron Worrell | Miami Dolphins | 56 | 0 | 0 | 0 |
| Abram Elam | New York Jets | 53 | 0 | 0 | 0 |
| Chris Hope | Tennessee Titans | 49 | 0 | 0 | 2 |
| Hamza Abdullah | Denver Broncos | 48 | 0 | 2 | 0 |
| Adrian Wilson | Arizona Cardinals | 44 | 0 | 0 | 2 |
| Eric Smith | New York Jets | 40 | 0 | 0 | 0 |
| Lance Schulters | Miami Dolphins | 37 | 0 | 0 | 0 |
| Sean Considine | Philadelphia Eagles | 35 | 0 | 0 | 1 |
| Oliver Celestin | Arizona Cardinals | 12 | 0 | 0 | 0 |
| Vernon Fox | Washington Redskins | 12 | 0 | 0 | 0 |
| Travares Tillman | Miami Dolphins | 11 | 0 | 0 | 0 |
| Yeremiah Bell | Miami Dolphins | 5 | 0 | 0 | 0 |
| Mike Brown | Chicago Bears | 4 | 0 | 0 | 1 |
| Gerald Sensabaugh | Jacksonville Jaguars | 3 | 0 | 0 | 0 |
| Daniel Bullocks | Detroit Lions | 0 | 0 | 0 | 0 |
| Glenn Earl | Houston Texans | 0 | 0 | 0 | 0 |